Michael J Welsh Selected Research

Anions

1/2020	Acidic Submucosal Gland pH and Elevated Protein Concentration Produce Abnormal Cystic Fibrosis Mucus.
1/2018	Ivacaftor-induced sweat chloride reductions correlate with increases in airway surface liquid pH in cystic fibrosis.
9/2017	Postnatal airway growth in cystic fibrosis piglets.
5/2016	Relationships among CFTR expression, HCO3- secretion, and host defense may inform gene- and cell-based cystic fibrosis therapies.
1/2016	Airway acidification initiates host defense abnormalities in cystic fibrosis mice.
1/2016	Repurposing tromethamine as inhaled therapy to treat CF airway disease.
1/2016	Lentiviral-mediated phenotypic correction of cystic fibrosis pigs.
6/2011	Human cystic fibrosis airway epithelia have reduced Cl- conductance but not increased Na+ conductance.
3/2011	The ΔF508 mutation causes CFTR misprocessing and cystic fibrosis-like disease in pigs.
1/2011	Enamel pathology resulting from loss of function in the cystic fibrosis transmembrane conductance regulator in a porcine animal model.

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Michael J Welsh Research Topics

Disease

41	Cystic Fibrosis (Mucoviscidosis) 01/2022 - 03/2002
11	Inflammation (Inflammations) 01/2022 - 12/2007
10	Acidosis 01/2017 - 02/2003
6	Lung Diseases (Lung Disease) 01/2022 - 12/2010
5	Infections 12/2021 - 11/2010
3	Seizures (Absence Seizure) 07/2015 - 10/2006
3	Brain Ischemia (Cerebral Ischemia) 09/2014 - 02/2003
3	Ischemia 10/2006 - 02/2000
2	Parkinson Disease (Parkinson's Disease) 01/2022 - 10/2019
2	Persistent Infection 01/2018 - 09/2012
2	Traumatic Brain Injuries (Traumatic Brain Injury) 09/2014 - 01/2013
2	Stroke (Strokes) 09/2014 - 09/2004
2	Hypersensitivity (Allergy) 03/2014 - 12/2003
2	Meconium Ileus 06/2013 - 09/2008
2	Charcot-Marie-Tooth Disease (Peroneal Muscular Atrophy) 09/2010 - 10/2006
2	Muscular Diseases (Myopathy) 11/2007 - 01/2004
2	Bacterial Infections (Bacterial Infection) 06/2005 - 03/2004
1	Bronchiectasis 12/2021
1	Prostatic Hyperplasia (Benign Prostatic Hyperplasia) 01/2021
1	Neurodegenerative Diseases (Neurodegenerative Disease) 10/2019
1	Fibrosis (Cirrhosis) 01/2019
1	Asthma (Bronchial Asthma) 01/2018
1	B-Cell Lymphoma (Lymphoma, B Cell) 04/2016
1	Drug Resistant Epilepsy 07/2015
1	Epilepsy (Aura) 07/2015
1	Apnea 07/2015
1	Sinusitis 02/2015
1	Glucose Intolerance 01/2015
1	Hypertension (High Blood Pressure) 11/2014
1	Necrosis 09/2014
1	Substance-Related Disorders (Drug Abuse) 08/2014
1	Chronic Obstructive Pulmonary Disease (COPD) 03/2014
1	Acne Vulgaris 08/2011
1	Pneumonia (Pneumonitis) 11/2010
1	Malnutrition (Nutritional Deficiencies) 11/2010
1	Spinal Muscular Atrophy (Progressive Muscular Atrophy) 09/2010
1	Motor Neuron Disease (Primary Lateral Sclerosis) 09/2010

Drug/Important Bio-Agent (IBA)

24	Cystic Fibrosis Transmembrane Conductance Regulator (Protein, CFTR)IBA 01/2022 - 02/2003
11	AnionsIBA 01/2020 - 12/2010
8	Proteins (Proteins, Gene)FDA Link 01/2020 - 01/2007
8	Acid Sensing Ion ChannelsIBA 01/2017 - 12/2003
6	ivacaftorIBA 12/2021 - 02/2015
6	Small Heat-Shock ProteinsIBA 09/2010 - 02/2000
4	ChloridesIBA 12/2021 - 03/2002
4	CalciumIBA 04/2016 - 04/2004
4	AcidsIBA 01/2013 - 02/2003
3	Protons (Proton)IBA 06/2014 - 10/2006
2	Terazosin (Hytrin)FDA LinkGeneric 01/2022 - 01/2021
2	Amphotericin B (Amphotericin)FDA LinkGeneric 01/2021 - 01/2019
2	Interleukin-17 (Interleukin 17)IBA 01/2021 - 01/2020
2	Bicarbonates (Hydrogen Carbonate)IBA 10/2020 - 01/2013
2	MucinsIBA 01/2017 - 04/2016
2	ElectrolytesIBA 01/2016 - 12/2010
2	Glutamic Acid (Glutamate)FDA Link 09/2014 - 09/2004
2	Complementary DNA (cDNA)IBA 06/2013 - 12/2005
2	Crystallins (Crystallin)IBA 11/2007 - 02/2000
2	Heat-Shock Proteins (Heat-Shock Protein)IBA 07/2004 - 02/2000
2	Amiloride (Midamor)FDA LinkGeneric 04/2004 - 12/2003
1	DisulfidesIBA 01/2022
1	Anti-Bacterial Agents (Antibiotics)IBA 12/2021
1	Tamsulosin (Flomax)FDA LinkGeneric 01/2021
1	Doxazosin (Cardura)FDA LinkGeneric 01/2021
1	CytokinesIBA 01/2021
1	alfuzosin (UroXatral)FDA Link 01/2021
1	Ion Channels (Ion Channel)IBA 01/2019
1	Bronchodilator Agents (Bronchodilators)IBA 01/2018
1	flunisolide (AeroBid)FDA LinkGeneric 01/2018
1	LactoferrinIBA 04/2016
1	TubulinIBA 04/2016
1	Peroxidase (Myeloperoxidase)IBA 04/2016
1	BuffersIBA 01/2016
1	Tromethamine (Trometamol)FDA Link 01/2016
1	Oxygen (Dioxygen)IBA 07/2015
1	Glucose (Dextrose)FDA LinkGeneric 01/2015
1	Complex MixturesIBA 12/2014
1	Serine (L-Serine)FDA Link 09/2014
1	ChromatinIBA 09/2014
1	Histones (Histone)IBA 09/2014
1	Biomarkers (Surrogate Marker)IBA 09/2014
1	mitogen and stress-activated protein kinase 1IBA 09/2014
1	Serotonin (5 Hydroxytryptamine)IBA 03/2014
1	SolventsIBA 03/2014
1	Neuropeptide Receptors (Neuropeptide Receptor)IBA 03/2014
1	MicroRNAs (MicroRNA)IBA 10/2013
1	Fatty Acid-Binding ProteinsIBA 06/2013
1	Messenger RNA (mRNA)IBA 06/2013
1	Lactic Acid (Lactate)FDA LinkGeneric 05/2012
1	SaltsIBA 05/2012
1	XylitolIBA 05/2012
1	thiocyanateIBA 05/2011
1	Adenosine Triphosphate (ATP)IBA 01/2011
1	SodiumIBA 12/2010
1	Insulin-Like PeptidesIBA 11/2010
1	Carbon DioxideIBA 11/2009

Therapy/Procedure

6	Therapeutics 01/2021 - 04/2008
3	Lasers (Laser) 11/2014 - 07/2009
2	Injections 07/2004 - 12/2003
1	Aftercare (After-Treatment) 12/2021
1	Electrodes (Electrode) 07/2015
1	Denervation 11/2014